Operation & Unit-Procedure Templates¶
Pre-built compositions of phase templates for common pharma sequences. Operations are ordered sequences of phases, and unit-procedure templates compose operations into a reusable procedure skeleton that a master recipe can bind to a specific unit.
Unit-Procedure Templates¶
The reference plant ships one CIP unit procedure template per unit type, all following the same structural pattern. Each is referenced directly from its corresponding CIP master recipe, with the pressure/leak-test step retained at the master-recipe level as a separate phase call.
| Template | Unit | Purpose |
|---|---|---|
| cip-vessel-cleaning | mix-tank-1 | Mix-tank CIP — pre-rinse, hot wash, rinses, conductivity check, blowdown. |
| reactor-cip-cycle | reactor-1 | Reactor CIP — pre-rinse, caustic wash, intermediate rinse, conditional acid wash, final rinse with pH endpoint. |
| fd-cip-cycle | filter-dryer-1 | Filter-dryer CIP — through-plate pre-rinse, hot wash, post-rinse. Drying and vent remain at the master-recipe level. |
Operation Templates¶
The generic mix-tank CIP operations use generic CIP phases
(cip-fill, cip-agitate, cip-heat-and-hold, cip-drain,
cip-conductivity-check, cip-pressurize, etc.) that bind to the
mix-tank's inlet_valve / outlet_valve / agitator roles. The
reactor and filter-dryer have different role topologies
(the reactor uses wfi_valve + outlet_valve + jacket_controller, and
the filter-dryer uses wash_valve + filtrate_valve + vacuum_controller)
so they get unit-specific phase templates, and the operation templates
below are thin wrappers over those unit-specific phases.
| Template | Unit scope | Purpose |
|---|---|---|
| cip-rinse-op | generic (mix-tank) | CIP rinse operation — fill with WFI, agitate, drain. |
| cip-hot-wash-op | generic (mix-tank) | CIP hot chemical wash — fill chemical, heat, agitate, drain. |
| cip-conductivity-rinse-op | generic (mix-tank) | Final rinse with conductivity endpoint verification. |
| cip-blowdown-op | generic (mix-tank) | N₂ blowdown — pressurize headspace and drain residuals. |
| reactor-cip-rinse-op | reactor | Reactor-specific WFI rinse — wraps the reactor-cip-rinse phase. |
| reactor-cip-hot-wash-op | reactor | Reactor-specific hot wash with optional skip — wraps the reactor-cip-hot-wash phase. |
| reactor-cip-ph-rinse-op | reactor | Reactor-specific final pH rinse — wraps the reactor-cip-ph-rinse phase. |
| fd-cip-rinse-op | filter-dryer | Through-plate rinse via vacuum — wraps the fd-cip-rinse phase. |
| fd-cip-hot-wash-op | filter-dryer | Through-plate hot wash with optional skip — wraps the fd-cip-hot-wash phase. |
Related Documentation¶
- Phase Templates — the building blocks
- Recipes — how operations fit in the ISA-88 cascade
- Master Recipes